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We have developed microfluidic devices for precise characterization of hematological diseases. By means of one drop of blood and combining front microfludics with mathematical models based on biomechanics, we analyze the properties of red blood cells and microrheological properties such as the viscosity of blood. We detect the advancement of microfronts of fluid inside microchannels. By means of statistical analysis we improve the diagnosis of hematological diseases. We predict if a sample of blood corresponds to healthy blood or to blood with an hematological disease. We have obtained different performance for the different methods, some of them with very good results and an accuracy of 94%.
Paulo Silva, Marcos Gouveia