Modeling the radiobiological effects of gold nanoparticles in proton therapy of glioblastomas
by
LIP-Lisboa/3-311 - Sala de Seminários
LIP Lisboa
Glioblastoma multiforme is a highly malignant brain tumor with strong resistance to conventional treatments, leading to poor prognosis. Improving therapeutic efficacy remains essential, and one promising approach involves tumor radiosensitization with high-Z nanoparticles, such as gold nanoparticles.
Since the radiosensitization effect depends on several physical and biological factors, including nanoparticle properties, cellular characteristics, and radiation type and energy, computational approaches such as Monte Carlo simulations are important tools for investigating these interactions.
In this seminar, I will present the outcome results of my PhD thesis, which explored the radiobiological impact of gold nanoparticles in glioblastoma radiotherapy, focusing on the role of nanoparticle characteristics, cellular modeling, and irradiation conditions in the assessment of radiosensitization effects